Scientific Advancements

SCIENTIFIC
ADVANCEMENTS AND PUBLICATIONS

Learn more about Sentinel’s cutting edge technology, tools, and scientific advancements.

Pathogen Detection Platform Advancements

CARMEN V1
Detect and destroy: CRISPR- based technologies for the response against viruses
Freije, C., Sabeti, P. et al. Cell Host & Microbe (2021)

CARMEN
Mutiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants
Welch, N. et al. Nature Medicine (2022) 5: 1083–1094.

SHINE
Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants
Arizti-Sanz, J. et al. Nature Biomedical Engineering (2022) May 30.

Assay Development

ADAPT
Designing sensitive viral diagnostics with machine learning.
Metsky, H.C. et al.
Nature Biotechnology (2022)1:108-119.

Sample Contamination Mitigation with SDSIs
Lagerborg, K. et al. Synthetic DNA spike-ins (SDSIs) enable sample tracking and detection of inter-sample contamination in SARS-CoV-2 sequencing workflows.
Nature Microbiology (2021), 7: 108–119.

SHINE
Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants
Arizti-Sanz, J. et al. Nature Biomedical Engineering (2022) May 30.

Pandemic Response and Impact

A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa.
Wilkinson, Eduan et al. Science (2021)

Genomic characterisation of multidrug-resistant pathogenic enteric bacteria from healthy children in Osun State, Nigeria.
Uwanibe JN, Olawoye IB, Happi CT, et al. bioRxiv [Preprint]. 2023 Jul 20:2023.07.19.549742. doi: 10.1101/2023.07.19.549742.

Detection of SARS-CoV-2 in terrestrial animals in southern Nigeria: potential cases of reverse zoonosis.
Happi AN, Ayinla AO, Ogunsanya OA, et al. Viruses, 2023 May 17;15(5):1187. doi: 10.3390/v15051187.

Urgent need for a non-discriminatory and non-stigmatizing nomenclature for monkeypox virus.
Happi, C., et al. Virological (June 10, 2022)

Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria.
Olawoye IB, Oluniyi PE, Oguzie JU, et al. Nat Commun, 2023;14, 811.

Two years of COVID-19 in Africa: lessons for the world.
Happi, C., Nkengasong, J. Nature (2022) 601: 22-25.

Two years of COVID-19 in Africa: lessons for the world.
Happi, C., Nkengasong, J. Nature (2022) 601: 22-25.

Metagenomic surveillance uncovers diverse and novel viral taxa in febrile patients from Nigeria.
Oguzie JU, Petros BA, Oluniyi PE, et al. Nature Comms. 2023 Aug 04. Article 4693.

SCIENTIFIC
ADVANCEMENTS AND PUBLICATIONS

Pathogen Detection Platform Advancements

CARMEN V1
Detect and destroy: CRISPR- based technologies for the response against viruses
Freije, C., Sabeti, P. et al. Cell Host & Microbe (2021)

CARMEN
Mutiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants
Welch, N. et al. Nature Medicine (2022) 5: 1083–1094.

SHINE
Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants
Arizti-Sanz, J. et al. Nature Biomedical Engineering (2022) May 30.

Assay Development

ADAPT
Designing sensitive viral diagnostics with machine learning.
Metsky, H.C. et al.
Nature Biotechnology (2022)1:108-119.

Sample Contamination Mitigation with SDSIs
Lagerborg, K. et al. Synthetic DNA spike-ins (SDSIs) enable sample tracking and detection of inter-sample contamination in SARS-CoV-2 sequencing workflows.
Nature Microbiology (2021), 7: 108–119.

SHINE
Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants
Arizti-Sanz, J. et al. Nature Biomedical Engineering (2022) May 30.

Pandemic Response and Impact

A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa.
Wilkinson, Eduan et al. Science (2021)

Genomic characterisation of multidrug-resistant pathogenic enteric bacteria from healthy children in Osun State, Nigeria.
Uwanibe JN, Olawoye IB, Happi CT, et al. bioRxiv [Preprint]. 2023 Jul 20:2023.07.19.549742. doi: 10.1101/2023.07.19.549742.

Detection of SARS-CoV-2 in terrestrial animals in southern Nigeria: potential cases of reverse zoonosis.
Happi AN, Ayinla AO, Ogunsanya OA, et al. Viruses, 2023 May 17;15(5):1187. doi: 10.3390/v15051187.

Urgent need for a non-discriminatory and non-stigmatizing nomenclature for monkeypox virus.
Happi, C., et al. Virological (June 10, 2022)

Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria.
Olawoye IB, Oluniyi PE, Oguzie JU, et al. Nat Commun, 2023;14, 811.

Two years of COVID-19 in Africa: lessons for the world.
Happi, C., Nkengasong, J. Nature (2022) 601: 22-25.

Two years of COVID-19 in Africa: lessons for the world.
Happi, C., Nkengasong, J. Nature (2022) 601: 22-25.

Metagenomic surveillance uncovers diverse and novel viral taxa in febrile patients from Nigeria.
Oguzie JU, Petros BA, Oluniyi PE, et al. Nature Comms. 2023 Aug 04. Article 4693.

Learn more about Sentinel's Impact

Learn more about our Scientific
Advancements

Learn how you can get involved

SCIENTIFIC ADVANCEMENTS AND PUBLICATIONS

Pathogen Detection Platform Advancements

CARMEN V1 Detect and destroy: CRISPR- based technologies for the response against viruses Freije, C., Sabeti, P. et al. Cell Host & Microbe (2021)

CARMEN Mutiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants Welch, N. et al. Nature Medicine (2022) 5: 1083–1094.

SHINE Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants Arizti-Sanz, J. et al. Nature Biomedical Engineering (2022) May 30.

Assay Development

ADAPT Designing sensitive viral diagnostics with machine learning. Metsky, H.C. et al. Nature Biotechnology (2022)1:108-119.

Sample Contamination Mitigation with SDSIs Lagerborg, K. et al. Synthetic DNA spike-ins (SDSIs) enable sample tracking and detection of inter-sample contamination in SARS-CoV-2 sequencing workflows. Nature Microbiology (2021), 7: 108–119.

SHINE Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants Arizti-Sanz, J. et al. Nature Biomedical Engineering (2022) May 30.

Pandemic Response and Impact

A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa. Wilkinson, Eduan et al. Science (2021)

Genomic characterisation of multidrug-resistant pathogenic enteric bacteria from healthy children in Osun State, Nigeria. Uwanibe JN, Olawoye IB, Happi CT, et al. bioRxiv [Preprint]. 2023 Jul 20:2023.07.19.549742. doi: 10.1101/2023.07.19.549742.

Detection of SARS-CoV-2 in terrestrial animals in southern Nigeria: potential cases of reverse zoonosis. Happi AN, Ayinla AO, Ogunsanya OA, et al. Viruses, 2023 May 17;15(5):1187. doi: 10.3390/v15051187.

Urgent need for a non-discriminatory and non-stigmatizing nomenclature for monkeypox virus. Happi, C., et al. Virological (June 10, 2022)

Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria. Olawoye IB, Oluniyi PE, Oguzie JU, et al. Nat Commun, 2023;14, 811.

Two years of COVID-19 in Africa: lessons for the world. Happi, C., Nkengasong, J. Nature (2022) 601: 22-25.

Two years of COVID-19 in Africa: lessons for the world. Happi, C., Nkengasong, J. Nature (2022) 601: 22-25.

Metagenomic surveillance uncovers diverse and novel viral taxa in febrile patients from Nigeria. Oguzie JU, Petros BA, Oluniyi PE, et al. Nature Comms. 2023 Aug 04. Article 4693.

Learn more about Sentinel's Impact

Learn more about our Scientific Advancements

Learn how you can get involved

SCIENTIFIC
ADVANCEMENTS AND PUBLICATIONS

CARMEN V1
Detect and destroy: CRISPR- based technologies for the response against viruses
Freije, C., Sabeti, P. et al. Cell Host & Microbe (2021)

CARMEN
Mutiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants
Welch, N. et al. Nature Medicine (2022) 5: 1083–1094.

SHINE
Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants
Arizti-Sanz, J. et al. Nature Biomedical Engineering (2022) May 30.

ADAPT
Designing sensitive viral diagnostics with machine learning.
Metsky, H.C. et al.
Nature Biotechnology (2022)1:108-119.

Sample Contamination Mitigation with SDSIs
Lagerborg, K. et al. Synthetic DNA spike-ins (SDSIs) enable sample tracking and detection of inter-sample contamination in SARS-CoV-2 sequencing workflows.
Nature Microbiology (2021), 7: 108–119.

SHINE
Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants
Arizti-Sanz, J. et al. Nature Biomedical Engineering (2022) May 30.

A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa.
Wilkinson, Eduan et al. Science (2021)

Genomic characterisation of multidrug-resistant pathogenic enteric bacteria from healthy children in Osun State, Nigeria.
Uwanibe JN, Olawoye IB, Happi CT, et al. bioRxiv [Preprint]. 2023 Jul 20:2023.07.19.549742. doi: 10.1101/2023.07.19.549742.

Detection of SARS-CoV-2 in terrestrial animals in southern Nigeria: potential cases of reverse zoonosis.
Happi AN, Ayinla AO, Ogunsanya OA, et al. Viruses, 2023 May 17;15(5):1187. doi: 10.3390/v15051187.

Urgent need for a non-discriminatory and non-stigmatizing nomenclature for monkeypox virus.
Happi, C., et al. Virological (June 10, 2022)

Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria.
Olawoye IB, Oluniyi PE, Oguzie JU, et al. Nat Commun, 2023;14, 811.

Two years of COVID-19 in Africa: lessons for the world.
Happi, C., Nkengasong, J. Nature (2022) 601: 22-25.

Two years of COVID-19 in Africa: lessons for the world.
Happi, C., Nkengasong, J. Nature (2022) 601: 22-25.

Metagenomic surveillance uncovers diverse and novel viral taxa in febrile patients from Nigeria.
Oguzie JU, Petros BA, Oluniyi PE, et al. Nature Comms. 2023 Aug 04. Article 4693.

Learn more about our Scientific
Advancements